Comparison of the effects of TRH and D-Ala2-metenkephalinamide on hippocampal electrical activity and behavior in the unanesthetized rat |
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Authors: | Eugene G. Drust Isaac L. Crawford |
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Affiliation: | 1. Department of Pharmacology, University of Texas Health Science Center at Dallas, Dallas TX 75216, USA;2. Department of Neurology, University of Texas Health Science Center at Dallas, Dallas TX 75216, USA;3. Laboratory of Neurophysiology (151), Southwestern Regional VA Epilepsy Center, Dallas TX 75216, USA;4. Veterans Administration Medical Center, 4500 S. Lancaster Rd., Dallas TX 75216, USA |
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Abstract: | Administration of TRH into the lateral ventricle of unanesthetized rats produced increases in the incidence of hippocampal theta (5.9–9.1 Hz) rhythm, locomotor activity and shaking behavior. The increase in theta rhythm produced by TRH was brief (<5 min) and was coincident with a brief, large increase in locomotor activity. Intracerebroventricular injection of either TRH or D-Ala2-metenkephalinamide (D-Ala2-ME) also induced episodes of shaking behavior. Shakes induced by D-Ala2-ME were associated with the occurrence of hippocampal epileptiform activity whereas those caused by TRH occurred in the absence of any recorded abnormalities in hippocampal activity. These results suggest that the increase in hippocampal theta rhythm after TRH is secondary to the increase in locomotor activity and, that in contrast to enkephalins, shaking behavior caused by TRH may not be related to an action on the electrographic activity of the hippocampus. |
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Keywords: | Thyrotropin-releasing hormone (TRH) Hippocampus Theta rhythm Hippocampal seizures Locomotor activity Shaking behavior |
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