Effects of x-irradiation on glycogenolysis,glycogenesis and gluconeogenesis in the rat |
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| Authors: | MCKEE R W BRIN M |
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| Affiliation: | 1. School of Pharmacy, Anhui Medical University, Hefei, 230032 Anhui, China;2. The First Clinical College of Anhui Medical University, Hefei, 230032 Anhui, China;1. Grupo Fisiopatología Endocrina, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS).;2. CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain;3. Department of Physiology, Research Centre of Molecular Medicine and Chronic Diseases (CIMUS), Santiago de Compostela, Spain;4. Pediatric Department, Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain;5. Cellular and Molecular Cardiology Research Unit and Department of Cardiology, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain;6. Servicio de Cirugía General, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain;7. Laboratorio de Endocrinología Molecular y Celular, Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain;8. Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain |
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| Abstract: | In the x-irradiated and fasted rat, the liver undergoes, during the first 8–10 hr. postirradiation, a fall in glycogen similar to that seen in the nonirradiated, fasted rat. This is followed in the irradiated animal by a striking increase in the liver glycogen which reaches a maximum in about 50 hr. There follows a precipitous fall with the glycogen values reaching abnormally low values in 75–80 hr. A similar rapid rise and fall in the liver glycogen was seen when fasting preceded the irradiation. A comparable increase, but progressively smaller influence, is seen when the total body x-irradiation is decreased to 250 r.Blood-sugar values increased to high normal nonfasting levels during the period of fasting and simultaneous with excessive glycogen synthesis. The blood-sugar levels began falling as the liver glycogen values fell. Excess glucose is handled normally as indicated by tolerance tests.Adrenalectomy and hypophysectomy prevented these changes in the x-irradiated rats indicating a strong gluconeogenic influence.X-irradiation of one of a pair of parabiot rats produced this same glycogenic effect in the irradiated animal with a reflection of the effect in the nonirradiated animal of the pair. |
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