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Mitochondrial contribution to protein synthesis in cerebral cortex

Authors:	H R Mahler L R Jones W J Moore

Affiliation:	1. Department of Forest and Soil Sciences, Institute of Soil Research, University of Natural Resources and Life Sciences, Vienna, Austria;2. Department of Material Sciences and Process Engineering, Institute of Physics and Material Sciences, University of Natural Resources and Life Sciences, Vienna, Austria;3. Department of Geography, National Taiwan University, Taipei, Taiwan;4. Department of Geography, National Taiwan Normal University, Taipei, Taiwan;5. Department of Soil and Water Conservation, National Pingtung University of Science and Technology, Neipu, Taiwan;6. Department of Water – Atmosphere - Environment, Institute of Hydrobiology and Aquatic Ecosystem Management, University of Natural Resources and Life Sciences, Vienna, Austria;7. Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan;8. Department of Atmospheric Sciences, National Taiwan University, Taipei, Taiwan;9. WasserCluster Lunz, Lunz am See, Austria

Abstract:	Emetine (at 100 μg/ml) blocks the incorporation of ³H-leucine into the total protein of slices from rat cerebral cortex by > 95%; the block on the synthesis of cytosol proteins is quantitative. Under these conditions protein synthesis resistant to emetine is localized in a mitochondrial fraction that is sensitive to chloramphenicol at 100 μg/ml to the extent of ∼ 70%. We infer that some 15% of the proteins of cerebral cortex mitochondria formed during a 60 min period have been provided by their own protein synthesizing system.

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