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Functional grouping of osteoclast genes revealed through microarray analysis |
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| Authors: | Yang Guozhe Zaidi Mone Zhang Weijia Zhu Ling-Ling Li Jianhua Iqbal Jameel Varbanov Alex Gross Gary Phipps Roger Troen Bruce R Sun Li |
| Institution: | a Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA b Bioinformatics Laboratory of Personalized Medicine Research Program, Department of Medicine, Mount Sinai School of Medicine, NY, USA c Procter and Gamble Pharmaceuticals, Mason, OH, USA d Miami VAMC Geriatric Research Education and Clinical Center and Research Service, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA |
| Abstract: | We describe for the first time functional clusters of genes that are modulated during the differentiation of osteoclasts. Pathway analysis was applied to gene array data generated from affymetrix chips hybridized to RNA isolated from RAW264.7 cells exposed to RANK-ligand (RANK-L) for 5 days. This analysis revealed major functional gene clusters that were either up- or down-regulated during osteoclastogenesis. Some of the genes within the clusters have known functions, while others do not. We discuss herein the relevance of these functional gene clusters and their modulation to biological processes underlying the formation, function, and fate of osteoclasts. |
| Keywords: | Osteoclast Microarray Osteoclastogenesis RANK-L |
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