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Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I |
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| Authors: | Parihar Mordhwaj S Nazarewicz Rafal R Kincaid Erick Bringold Urs Ghafourifar Pedram |
| Institution: | a Department of Surgery, Davis Heart and Lung Research Institute, and Institute of Mitochondrial Biology, The Ohio State University, Columbus, OH, USA b Zebrafish GmbH, Basel, Switzerland |
| Abstract: | The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions. |
| Keywords: | RCC-I respiratory chain complex I RCC-II respiratory chain complex II NO nitric oxide mtNOS mitochondrial nitric oxide synthase l-NMMA" target="_blank">l-NMMA l-arginine" target="_blank">NG-monomethyl-l-arginine Rot rotenone Succ succinate Pyr Pyruvate Mal malate |
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