Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B) |
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Authors: | Gevorkian Goar Gonzalez-Noriega Alfonso Acero Gonzalo Ordoñez Jorge Michalak Colette Munguia Maria Elena Govezensky Tzipe Cribbs David H Manoutcharian Karen |
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Institution: | Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Apartado Postal 70228, Cuidad Universitaria, Mexico DF, CP 04510, Mexico. gokar@servidor.unam.mx |
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Abstract: | Extracellular and intraneuronal formation of amyloid-beta aggregates have been demonstrated to be involved in the pathogenesis of Alzheimer's disease. However, the precise mechanism of amyloid-beta neurotoxicity is not completely understood. Previous studies suggest that binding of amyloid-beta to a number of targets have deleterious effects on cellular functions. In the present study we have shown for the first time that amyloid-beta 1-42 bound to a peptide comprising the microtubule binding domain of the heavy chain of microtubule-associated protein 1B by the screening of a human brain cDNA library expressed on M13 phage. This interaction may explain, in part, the loss of neuronal cytoskeletal integrity, impairment of microtubule-dependent transport and synaptic dysfunction observed previously in Alzheimer's disease. |
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