Effect of Copper on Levels of Collagen and Alkaline Phosphatase Activity from Chondrocytes in Newborn Piglets In Vitro |
| |
Authors: | Xue Yuan Jianguo Wang Xiaoyan Zhu Zhigang Zhang Yongxing Ai Guoquan Sun Zhe Wang Guowen Liu |
| |
Affiliation: | College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, 130062, China. |
| |
Abstract: | The effects of different concentrations of copper on collagen content and alkaline phosphatase (AKP) activity from chondrocytes in newborn piglets were measured. Chondrocytes were cultured in media containing 15% fetal calf serum supplemented with 0, 15.6, 31.2, and 62.5?μmol/L copper in a 12-well culture plate. Collagen content and AKP activity from the chondrocyte extracellular matrix increased significantly in the culture media with 15.6, 31.2, and 62.5?μmol/L copper and was the highest at 31.2?μmol/L copper (P?0.05). Thus, the results indicated that copper could promote AKP activity and collagen production by chondrocytes. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|