Effects of cold stress on glutathione and related enzymes in rat erythrocytes |
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| Authors: | Hideki Ohno Takahito Kondo Yutaka Fujiwara Sei-ichi Tagami Akihiro Kuroshima Yoshikazu Kawakami |
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| Affiliation: | (1) Department of Hygiene, National Defense Medical College, 3-2, Namiki, 359 Tokorozawa, Japan;(2) First Department of Internal Medicine, Hokkaido University School of Medicine, 060 Sapporo, Japan;(3) First Department of Physiology, Asahikawa Medical College, 078 Asahikawa, Japan |
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| Abstract: | Effects of acute and chronic cold stress on glutathione and related enzymes in rat erythrocytes were investigated. Blood from both cold-acclimated (CA) and cold-adapted (CG) rats had significantly lower concentrations of glutathione than blood from control animals. Superoxide dismutase activity was increased significantly in CA rats and tended to rise in CG rats. Activity of glutathione peroxidase in erythrocytes was inconsistent in that it tended to increase in CA rats but decreased significantly in CG rats. The results may imply that CG rats suffered deleterious effects of hydrogen peroxide. On the other hand, there were marked decreases in glutathione peroxidase and glutathione reductase activities in acutely cold-exposed rats in conjunction with unchanged levels of glutathione. In all treatments the state of riboflavin metabolism was estimated to be adequate, since no increases were observed in the erythrocyte glutathione reductase activity coefficient. |
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| Keywords: | Cold stress Glutathione Antioxidant enzymes Rat erythrocytes |
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