Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types |
| |
| Authors: | Taylor Craig J Peacock Sarah Chaudhry Afzal N Bradley J Andrew Bolton Eleanor M |
| |
| Institution: | Histocompatibility and Immunogenetics Laboratory, Cambridge University Teaching Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. craig.taylor@addenbrookes.nhs.uk |
| |
| Abstract: | The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
