Magnetic particle imaging for artifact-free imaging of intracranial flow diverter stents: A phantom study |
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| Institution: | 1. Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, 97080 Würzburg, Germany;2. Department of Experimental Physics 5 (Biophysics), University of Würzburg, 97074 Würzburg, Germany;3. Department of Neuroradiology, University Hospital Bonn, 53127 Bonn, Germany;4. Department of Diagnostic and Interventional Neuroradiology, University Hospital Würzburg, 97080 Würzburg, Germany;1. Department of Computer Science, Shantou University, Shantou, Guangdong, China;2. College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China;1. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy;2. Medical Physics, San Raffaele Scientific Institute, Milano, Italy;3. Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy;4. Health Physics Unit, ASST Santi Paolo e Carlo, Milan, Italy;5. Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy;6. Università di Napoli Federico II, Dipartimento di Fisica “Ettore Pancini”, Napoli, Italy;7. Medical Physics Unit, Azienda Ospedaliera Universitaria Integrata – Verona, Italy;8. Unit of Radiation Research, IEO European Institute of Oncology, IRCCS, Milano, Italy;1. Medical Imaging Research Center, KU Leuven, Herestraat 49, 3000 Leuven, Belgium;2. Department of Radiology, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium;3. Clinical Hospital Center of Montenegro, Podgorica, Montenegro;4. SCK•CEN Belgian Nuclear Research Center, Boeretang 200, 2400 Mol, Belgium;5. QCC-Gent, Centrum voor medische stralingsfysica in de radiologie en nucleaire geneeskunde Universiteit Gent, Proeftuinstraat 86, gebouw N7, 9000 Gent, Belgium;6. Medical Physics Department - Radiology, Liège University Hospital, B35 Sart Tilman, 4000 Liège, Belgium;1. QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Japan;2. Association for Nuclear Technology in Medicine, Japan;3. Tokyo Bay Advanced Imaging & Radiation Oncology Makuhari Clinic, Japan;4. Aichi Cancer Center Hospital, Japan;5. Komazawa University, Japan;6. Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan;7. Graduate School of Medicine, Kyoto University, Japan |
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| Abstract: | PurposeMagnetic Particle Imaging (MPI) is a new, background- and radiation-free tomographic imaging method that enables near real-time imaging of superparamagnetic iron-oxide nanoparticles (SPIONs) with high temporal and spatial resolution. This phantom study aims to investigate the potential of MPI for visualization of the stent lumen in intracranial flow diverters (FD).MethodsNitinol FD of different dimensions (outer diameter: 3.5 mm, 4.0 mm, 5.5 mm; total length: 22–40 mm) were scanned in vascular phantoms in a custom-built MPI scanner (in-plane resolution: ~ 2 mm, field of view: 65 mm length, 29 mm diameter). Phantoms were filled with diluted (1:50) SPION tracer agent Ferucarbotran (10 µmol (Fe)/ml; NaCL). Each phantom was measured in 32 different projections (overall acquisition time per image: 3200 ms, 5 averages). After image reconstruction from raw data, two radiologists assessed image quality using a 5-point Likert scale. The signal intensity profile was measured using a semi-automatic evaluation tool.ResultsMPI visualized the lumen of all FD without relevant differences between the stented vessel phantom and the reference phantom. At 3.5 mm image quality was slightly inferior to the larger diameters. The FD themselves neither generated an MPI signal nor did they lead to relevant imaging artifacts. Ratings of both radiologists showed no significant difference, interrater reliability was good (ICC 0.84). A quantitative evaluation of the signal intensity profile did not reveal any significant differences (p > 0.05) either.ConclusionMPI visualizes the lumen of nitinol FD stents in vessel phantoms without relevant stent-induced artifacts. |
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| Keywords: | Magnetic particle Imaging MPI Flow Diverter Stent Aneurysm |
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