Antiparasitic antibiotics from Japan |
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Institution: | 1. Research Center for Neglected Diseases, Guarulhos University, Guarulhos, SP, Brazil;2. Institute of Parasitology, McGill University, Montreal, QC, Canada;3. School of Biological Sciences, Queen’s University, Belfast, UK |
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Abstract: | Antibiotics are microbial secondary metabolites and they are important for the treatment of infectious diseases. Japanese researchers have made a large contribution to studies of antibiotics, and they have also been important in the discovery of antiparasitic antibiotics. Satoshi ōmura received the Nobel Prize in 2015 for the “discoveries concerning a novel therapy against infections caused by roundworm parasites”, which means discovery of a new nematocidal antibiotic, avermectin. Here, I review the many antiparasitic antibiotics and their lead compounds that have been discovered for use in human and veterinary medicine. |
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