Peptides for disrupting and degrading amyloids |
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| Institution: | 1. Institute for Protein research, Osaka University, Yamadaoka 3-2, Suita, Osaka 565-0871, Japan;2. Protein Structure Research Group, Division of Bioconvergence Analysis, Korea Basic Science Institute, Chungcheongbuk-do 28119, South Korea;3. Department of Chemistry, Sookmyung Women''s University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul 04310, South Korea;4. Biophysics and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA;5. Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA;1. Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK;1. Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300354, China;2. Key Laboratory of Industrial Fermentation Microbiology (Ministry of Education), Tianjin University of Science & Technology, Tianjin 300457, China;3. Tianjin Key Laboratory of Industrial Microbiology, Tianjin University of Science & Technology, Tianjin 300457, China;4. National Engineering Laboratory for Industrial Enzymes, Tianjin University of Science & Technology, Tianjin 300457, China;5. National and Local United Engineering Lab of Metabolic Control Fermentation Technology, Tianjin University of Science & Technology, Tianjin 300457, China;6. College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China;7. Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH 44325, United States |
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| Abstract: | Amyloid proteins can aggregate into insoluble fibrils and form amyloid deposits in the human brain, which is the hallmark of many neurodegenerative diseases. Promising strategies toward pathological amyloid proteins and deposition include investigating inhibitors that can disrupt amyloid aggregation or induce misfolding protein degradation. In this review, recent progress of peptide-based inhibitors, including amyloid sequence–derived inhibitors, designed peptides, and peptide mimics, is highlighted. Based on the increased understanding of peptide design and precise amyloid structures, these peptides exhibit advanced inhibitory activities against fibrous aggregation as well as enhanced druggability. |
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| Keywords: | Peptide inhibitor Amyloid Protein degradation Aggregation |
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