Design and optimizing a novel ocular plaque brachytherapy with dual-core of 103Pd and 106Ru |
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| Institution: | 1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran;2. Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran;3. Medical Physics Department, School of Medicine, Iran University of Medical Sciences, P.O. Box: 14155-6183 Tehran, Iran;1. Trillium Health Partners, Peel Regional Cancer Centre, Mississauga, ON, Canada;2. University of Toronto, Department of Radiation Oncology, Toronto, ON, Canada;3. University of Ryerson, Department of Physics, Toronto, Canada;4. Sunnybrook Health Sciences Centre, Toronto, Canada;5. York University, Department of Physics and Astronomy, Toronto, ON, Canada;1. Department of Medical Physics, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045, Japan;2. Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashioku, Arakawa-ku Tokyo 116-8551, Japan;3. Division of Research and Development for Boron Neutron Capture Therapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan;4. Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045, Japan;1. Department of Medical Physics and Radiation Protection, Hospital Universitario La Paz, Madrid, Spain;2. Servicio de Radiofísica y Protección Radiológica, ESI/OSI Donostialdea, Donostia, Spain;3. Department of Nuclear Medicine, Hospital Universitario La Paz, Madrid, Spain;4. Servicio de Radiofísica y Protección Radiológica. Hospital Universitario Rey Juan Carlos, Madrid, Spain;5. Independent researcher, Madrid, Spain;1. Plasma Physics and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran;2. Energy Engineering and Physics Department, Amirkabir University of Technology, Tehran, Iran;3. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran;1. Division of Medical Physics, Department of Information Technology and Medical Engineering, Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;2. Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;3. Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan;4. Kansai BNCT Medical Center, Osaka Medical College, 2-7 Daigaku-Machi, Takatsuki, Osaka 569-8686, Japan;5. Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2 Asashiro-nishi Kumatori-cho, Osaka 590-0494, Japan |
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| Abstract: | In recent decades, eye plaques of brachytherapy have been extensively used as primary treatment as well as a complementary treatment for ocular cancer. The purpose of this study is the development of the eye plaque brachytherapy throughout a new design of eye plaque by combining the COMS plaque and the CCB BEBIG plaque loaded by IRA1-103Pd and 106Ru, respectively. A new dual-core plaque with a diameter of 20 mm was designed in the way that the BEBIG plaque with a diameter of 20 mm loaded by 106Ru plate is attached to the COMS plaque with a diameter of 20 mm loaded by 24 of IRA1-103Pd seeds. Dose calculations for the new plaque were performed by using the MCNP5 code. Dose calculations of dual-core plaque including 103Pd seeds (gamma) and 106Ru plate (beta) were separately done for the sake of MCNP constraints in gamma and beta particle transfer simultaneously. The new dual-core plaque delivers a much higher dose rate to the tumor compared with every single plaque, while the dose rate reached to healthy tissues is slightly higher than each plaque separately. Of course, this is acceptable because the treatment time reduces and subsequently the error in radiation therapy reduces. |
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