Complete genome of a dengue virus serotype 4 strain from Amazonas,
Brazil |
| |
| Authors: | Valdinete Alves do Nascimento Victor Costa de Souza Felipe Gomes Naveca |
| |
| Institution: | 1.Fundação Oswaldo Cruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil;2.Universidade Federal do Amazonas, Programa de Pós-Graduação em Saúde, Sociedade e Endemias na Amazônia, Manaus, AM, Brasil |
| |
| Abstract: | Dengue virus (DENV) infections represent a significant concern for public health
worldwide, being considered as the most prevalent arthropod-borne virus regarding the
number of reported cases. In this study, we report the complete genome sequencing of
a DENV serotype 4 isolate, genotype II, obtained in the city of Manaus, directly from
the serum sample, applying Ion Torrent sequencing technology. The use of a massive
sequencing technology allowed the detection of two variable sites, one in the coding
region for the viral envelope protein and the other in the nonstructural 1 coding
region within viral populations. |
| |
| Keywords: | Brazilian Amazon dengue virus DENV-4 viral genome next-generation sequencing |
|
|
