Quantitative autoradiography in boron neutron capture therapy considering the particle ranges in the samples |
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| Affiliation: | 1. Particle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka, Japan;2. Department of Radiation Oncology and Image-Applied Therapy, Kyoto University, Kyoto, Japan;1. Center for Evidence-Based Imaging (CEBI), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;2. Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;3. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA;4. Takeda Pharmaceuticals, Boston, MA, USA;1. S. Giovanni Calibita Hospital, Fatebenefratelli Hospital, Isola Tiberina, Department of Radiology, Rome, Italy;2. S. Giovanni Calibita, Fatebenefratelli Hospital, Isola Tiberina, Department of Medical Physics, Rome, Italy;3. ASL Roma 1, PO San Filippo Neri, Department of Medical Physics, Rome, Italy;4. Ospedali Riuniti Marche Nord, Department of Medical Physics and High Technologies, Pesaro, Italy;5. S. Giovanni Calibita Hospital, Fatebenefratelli Hospital, Isola Tiberina, Arrhythmology Unit, Rome, Italy;6. Department of Public Health and Infectious Diseases, Section of Health Statistics and Biometry, Sapienza University of Rome, Italy;7. Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy;1. Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pisa, I-56126 Pisa, Italy;2. Dipartimento di Scienze Fisiche, della Terra e dell’Ambiente, Universitá di Siena, I-53100 Siena, Italy;3. Dipartimento di Scienze Biomediche Sperimentali e Cliniche (SBSC), Universitá di Firenze, I-50134 Florence, Italy;1. Centro Nazionale di Adroterapia Oncologica CNAO, Clinical Department-Bioengineering Unit, Pavia, Italy;2. Center of Proton Therapy, Paul Scherrer Institut, 5232 Villigen, PSI, Switzerland;3. Centro Nazionale di Adroterapia Oncologica CNAO, Clinical Department, Pavia, Italy;4. Centro Nazionale di Adroterapia Oncologica CNAO, Particle Accelerator Department, Pavia, Italy;5. Centro Nazionale di Adroterapia Oncologica CNAO, Clinical Department - Medical Physics Unit, Pavia, Italy;6. Politecnico di Milano, Department of Electronics Information and Bioengineering, Milano, Italy;1. Instituto de Física, Universidad Nacional Autónoma de México, A. P. 20-364, Ciudad de México 01000, Mexico;2. Escuela Superior de Física y Matemáticas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico;1. Department of Physics, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, 14040-901, Monte Alegre, Ribeirão Preto, São Paulo, Brazil;2. São Carlos Radiotherapy Center, Rua Maestro João Seppe, s/n°, 13561-180, Jd. Paraíso, São Carlos, Brazil;3. Radiotherapy Department, Ribeirão Preto Medical School Hospital and Clinics, University of São Paulo, Av. Bandeirantes 3900, 14040-900, Monte Alegre, Ribeirão Preto, São Paulo, Brazil |
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| Abstract: | PurposeBoron neutron capture therapy is a cellular-scale particle therapy exploiting boron neutron capture reactions in boron compounds distributed in tumour cells. Its therapeutic effect depends on both the accumulation of boron in tumour cells and the neutron fluence. Autoradiography is used to visualise the micro-distribution of boron compounds.MethodsHere, we present an equation for the relationship between boron concentration and pit density on the solid-state nuclear track detector, taking into consideration the particle ranges in the samples. This equation is validated using liver-tissue sections and boron standard solutions. Moreover, we present a simple co-localisation system for pit and tissue-section images that requires no special equipment.ResultsThe equation reproduces the experimentally observed trends between boron concentration and pit density. This equation provides a theoretical explanation for the widely used calibration curve between pit density and boron concentration; it also provides a method to correct for differences of tissue-section thickness in quantitative autoradiography.ConclusionsUsing the equation together with this co-localisation system could improve micro-scale quantitative estimation in tissue sections. |
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| Keywords: | Boron neutron capture therapy Autoradiography Microdistribution |
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