Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease |
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| Institution: | 1. Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximillian University, Munich, Germany;2. Munich Cluster for Systems Neurology (SyNergy), Germany;3. Albert-Ludwigs-University, Freiburg, Germany;4. Institute of Neuropathology, Albert-Ludwigs-University, Freiburg, Germany;5. Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technical University, Munich, Germany;1. Department of Rheumatology, Shenzhen Hospital, Southern Medical University, 1333 Xinhu Road, Shenzhen 518100, China;2. Department of endocrinology, Shenzhen Hospital, Southern Medical University, 1333 Xinhu Road, Shenzhen 518100, China;3. Department of Radiology, Shenzhen Hospital, Southern Medical University, 1333 Xinhu Road, Shenzhen 518100, China |
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| Abstract: | Cases of inflammatory bowel disease (IBD), a debilitating intestinal disorder with complex pathological mechanisms, have been increasing in recent years, straining the capacity of healthcare systems. Thus, novel therapeutic targets and innovative agents must be developed. Notably, the NLRP3 inflammasome is upregulated in patients with IBD and/or in animal experimental models. As an innate immune supramolecular assembly, the NLRP3 inflammasome is persistently activated during the pathogenesis of IBD by multiple stimuli. Moreover, this protein complex regulates pro-inflammatory cytokines. Thus, targeting this multiprotein oligomer may offer a feasible way to relieve IBD symptoms and improve clinical outcomes. The mechanisms by which the NLRP3 inflammasome is activated, its role in IBD pathogenesis, and the drugs administered to target this protein complex are reviewed herein. This review establishes that the use of inflammasome-targeting drugs are effective for IBD treatment. Moreover, this review suggests that the value and potential of naturally sourced or derived medicines for IBD treatment must be recognized and appreciated. |
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| Keywords: | Inflammatory bowel disease NLRP3 inflammasome Targeted drug |
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