Supramolecular coordination complexes as diagnostic and therapeutic agents |
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| Institution: | 1. Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, United States;2. State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, Hangzhou, 310027, PR China;3. Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, PR China;4. Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore;1. School of Life Science, Chongqing University, Chongqing 400044, China;2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore;3. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China;1. Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea;2. School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China;1. Department of Chemistry, Pondicherry University, Puducherry, 605014, India;2. Department of Biotechnology, Pondicherry University, Puducherry, 605014, India;1. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, China;2. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, China;3. State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, China |
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| Abstract: | The metal-based drugs represented by cisplatin, carboplatin, and oxaliplatin, prevail in cancer treatment, whereas new therapeutics are extremely slow to step into the clinic. Poor pharmacokinetics, multidrug resistance, and severe side effects greatly limit the development of metal-based anticancer drugs. The robustness and modular composition of supramolecular coordination complexes allow for the incorporation of novel diagnostic and therapeutic modalities, showing promising potentials for precise cancer theranostics. In this mini review, we highlight the recent advances in the development of supramolecular coordination complexes as diagnostic and therapeutic agents. The key focuses of these reports lie in searching sophisticated coordination ligands and nanoformulations that can potentially solve the issues faced by current metal-based drugs including imaging, resistance, toxicity, and pharmacological deficiencies. |
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| Keywords: | Supramolecular coordination complex Theranostics Cancer Metals in medicine |
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