Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan,normal tissue complication probability model,and clinical outcomes in prostate cancer |
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| Institution: | 1. Cancer Center, School of Medicine, Keio University, Tokyo, Japan;2. Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan;3. Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan;4. Gunma University Heavy Ion Medical Center, Gunma, Japan;5. Osaka Heavy Ion Therapy Center, Osaka, Japan;6. International Science and Technology Center, Nur-Sultan, Kazakhstan;7. Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan |
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| Abstract: | This retrospective study assessed the treatment planning data and clinical outcomes for 152 prostate cancer patients: 76 consecutive patients treated by carbon-ion radiation therapy and 76 consequtive patients treated by moderate hypo-fractionated intensity-modulated photon radiation therapy. These two modalities were compared using linear quadratic model equivalent doses in 2 Gy per fraction for rectal or rectal wall dose–volume histogram, 3.6 Gy per fraction-converted rectal dose–volume histogram, normal tissue complication probability model, and actual clinical outcomes. Carbon-ion radiation therapy was predicted to have a lower probability of rectal adverse events than intensity-modulated photon radiation therapy based on dose–volume histograms and normal tissue complication probability model. There was no difference in the clinical outcome of rectal adverse events between the two modalities compared in this study. |
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| Keywords: | Carbon-ion radiation therapy Prostate cancer Normal tissue complication probability |
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