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Deoxyribonucleic acid strand breaks during freeze-drying and their repair in Escherichia coli. |
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| Authors: | T Ohnishi Y Tanaka M Yoh Y Takeda T Miwatani |
| Abstract: | Freeze-drying of Escherichia coli cells caused strand breaks of deoxyribonucleic acid (DNA) in both radiation-sensitive and -resistant strains. However, in the radiation-resistant strain E. coli B/r the damaged DNA was repaired after rehydration, whereas in the radiation-sensitive strain E. coli Bs-1 the damaged DNA was not repaired and the DNA was degraded. Repeated freeze-drying did not break the damaged DNA into smaller pieces. |
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