A muscle activation model of variable stimulation frequency response and stimulation history, based on positive feedback in calcium dynamics |
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Authors: | Gonzalo H Otazu Ryoko Futami Nozomu Hoshimiya |
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Institution: | (1) Graduate School of Engineering, Tohoku University, Aramaki aza aoba 05, Aoba-ku, Sendai 980-8579, Japan, JP |
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Abstract: | Muscle fiber response to a train of variable-frequency pulses includes the potentiation and catch-like effect. For better
understanding of these phenomena, we built an activation model with emphasis on the calcium liberation from and re-sequestration
into the sarcoplasmic reticulum, including calcium-induced calcium release. The model had two stable equilibrium points in
the calcium concentration. Changes from the low to the high equilibrium point could be produced by high-frequency trains of
pulses and would account for the potentiation. The model also showed a catch-like effect, as a long-lasting increment of muscle
force after the application of a single extra pulse. The increase in force appeared in resting muscle, disappeared when the
muscle was potentiated, and reappeared briefly if the stimulation was continued for long periods.
Received: 31 January 2000 / Accepted in revised form: 2 August 2000 |
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