Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series |
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| Authors: | Mente Nolan R Wiemer Andrew J Neighbors Jeffrey D Beutler John A Hohl Raymond J Wiemer David F |
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| Affiliation: | Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA. |
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| Abstract: | Total synthesis of the (R,R,R)- and (S,S,S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the natural product, as well as a variety of bioassay data, allow assignment of the natural material as the (R,R,R)-isomer. |
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