Interaction of DDT ( with liposomal phospholipids |
| |
Authors: | K. Buff J. Berndt |
| |
Affiliation: | Gesellschaft für Strahlen- und Umweltforschung München, Institut für Toxikologie und Biochemie, Abteilung für Zellchemie, 8042 Neuherberg F.R.G. |
| |
Abstract: | The influence of (DDT) and several other pesticides on the physical state of membrane phospholipids was investigated using model lipids. The thermal dependence of fluorescence intensity of the probe parinaric acid in dipalmitoylphosphatidylcholine liposomes and lipid vesicles of mixed composition were recorded. DDT was incorporated into the liposomal bilayer. The insecticide lowered the phase transition temperature and broadened the temperature range of the transition. The effects were concentration-dependent.The results may be interpreted as a sort of blurred and facilitated phase transition of bilayer lipids caused by intercalation of DDT between fatty acyl chains of membrane phospholipids. |
| |
Keywords: | DDT Liposome Parinaric acid Pesticide effect Phase transition Fluorescent probe DDT DDE DPPC glycero-1,2-dipalmitoyl-3-phosphatidylcholine DMPC glycero-1,2-dimyristoyl-3-phosphatidylcholine DOPC glycero-1,2-dioleoyl-3-phosphatidylcholine |
本文献已被 ScienceDirect 等数据库收录! |
|