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A statistical mechanical treatment of fatty acyl chain order in phospholipid bilayers and correlation with experimental data. B. Dipalmitoyl-3-sn-phosphatidylcholine
Authors:Jean-Paul Meraldi  Jürgen Schlitter
Institution:1. Department of Biophysical Chemistry, Biocenter of the University of Basel, Klingelbergstrasse 70, CH-4056 Basel Switzerland;2. Institute of Biophysics, University of Bochum ND/04, D-4630 Bochum F.R.G.
Abstract:In order to help bridge the conceptual gap between experimental data on chains of phospholipid molecules and their microscopic organization, a theoretical model has been proposed in a preceding paper. The intentions associated with the new theory were to describe a model able to reproduce accurately the experimental data. This capability is essential to monitor some of the mechanisms behind the physical data. The results presented here show first that, provided a suitable fitting of the phenomenological parameters entailed in the model, the theory indeed gives good agreement with experimental data (2H-NMR, neutron scattering, calorimetry) obtained for a dipalmitoyl-3-sn-phosphatidylcholine bilayer. This property of the model is then specifically used to describe the nature of the perturbing effects of local anaesthetics and cholesterol on the organization of the acyl chains and to correlate these effects with the experimental data. Finally the theoretical model is used to supplement experimental data by describing the acyl chain organization in terms of the most probable spectrum of chain conformations. Predictions are made about the one-, two- and three-dimensional mean spatial characteristics of the acyl chains.
Keywords:Phospholipid bilayer  Statistical mechanics  Phase transition  Conformational probability  Spatial chain characteristics
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