Na+-dependent,potential-sensitive l-ascorbate transport across brush border membrane vesicles from kidney cortex |
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Authors: | Gerhard Toggenburger,Max H?sermann,Beat Mütsch,Giulio Genoni,Markus Kessler,Fritz Weber,Dietrich Hornig,Brigitte O Neill,Giorgio Semenza |
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Affiliation: | 1. Laboratorium für Biochemie der E.T.H., Universitätstrasse 16, CH 8 092 Zürich, Switzerland;2. Department of Vitamin and Nutrition Research, F. Hoffmann-La Roche & Co., Ltd., Grenzacherstrasse 124, CH 4 002 Basle Switzerland |
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Abstract: | l-Ascorbate is taken up into brush border vesicles from kidney cortex of rat, rabbit and guinea pig by an efficient, Na+-dependent and potential-sensitive transport process. This uptake shows saturation () and is strongly stimulated by low concentrations of N3?. Erythorbate (d-isoascorbate) seems to be another, but poorer, substrate of the same transporter. |
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Keywords: | Potential dependence (Kidney cortex) DTT dithiothreitol FCCP Hepes Mes To whom correspondence and requests for reprints should be addressed. |
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