Dog kidney (Na+, K+)-ATPase is more sensitive to inhibition by vanadate than human red cell (Na+, K+)-ATPase |
| |
Authors: | Guy H. Bond Patricia M. Hudgins |
| |
Affiliation: | Department of Physiology, Kirksville College of Osteopathic Medicine, Kirksville, MO 63 501 U.S.A. |
| |
Abstract: | (Na+, K+)-ATPase (EC 3.6.1.3) from kidney is more sensitive to inhibition by vanadate than red cell (Na+,K+)-ATPase. The difference appears to be in the apparent affinities of the two enzymes for K+ and Na+ at sites where K+ promotes and Na+ opposes vanadate binding. As a result of Na+-K+ competition at these sites, reversal of vanadate inhibition was accomplished at lower Na+ concentrations in red cell than in kidney (Na+,K+)-ATPase. It is possible that vanadate could selectively regulate Na+ transport in the kidney. |
| |
Keywords: | Vanadate inhibition (Dog kidney Human red cell) |
本文献已被 ScienceDirect 等数据库收录! |
|