<Emphasis Type="Italic">L</Emphasis>-Glutamic Acid Modulates the Cytotoxic Effect of Tumor Necrosis Factor on the HL-60 Cell Line期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

L-Glutamic Acid Modulates the Cytotoxic Effect of Tumor Necrosis Factor on the HL-60 Cell Line

Authors:	N.?V.?Gibanova,T.?V.?Rakitina,S.?S.?Zhokhov,N.?M.?Pustoshilova,V.?M.?Lipkin,I.?A.?Kostanyan author-information" > author-information__contact u-icon-before" > mailto:iakost@mail.ibch.ru" title=" iakost@mail.ibch.ru" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia;(2) Research and Technology Institute of Biologically Active Substances, Vector State Scientific Center for Virology and Biotechnology, a/ya 112, Berdsk, Novosibirsk oblast, 633190, Russia

Abstract:	L-Glutamic acid was shown to increase the stability of cells of the HL-60 line of human promyelocyte leukemia to the cytotoxic action of tumor necrosis factor alpha (TNF-α) due to the inhibition of apoptotic and NF-κB-activating cascades induced by this cytokine. At the same time, L-glutamic acid increases the TNF-α-mediated differentiating signal and the accompanying enhancement of the phosphatidylinositol-specific phospholipase C activity. Therefore, it is a promising agent for the reduction of total toxicity and inflammatory processes during treatment with TNF-α.

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