Predictive indicators for the therapeutic effect of OK-432 in patients with chronic active type B hepatitis |
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Authors: | Kimio Nishimura Dr. Shigeaki Ishizaka Tadasu Tsujii |
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Affiliation: | (1) The Third Department of Internal Medicine, Nara Medical University, 840 Shijo-Cho, Kasahara, 634 Nara, Japan |
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Abstract: | Twenty-two patients with chronic type B hepatitis were treated with OK-432. Immunological parameters were serially measured to find predictive indicators for the seroconversion from hepatitis B envelope antigen(HBe Ag) to anti-HBe. In patients who achieved the disappearance of HBe Ag associated with or without the appearance of anti-HBe, the numbers of CD8+DR+ and CD4+DR+T cells in peripheral blood increased gradually during OK-432 therapy and then reduced subsequently to the seroconversion from HBe Ag positive to anti-HBe positive. Increases of DR-positive T cells in numbers were significantly correlated with increased amounts of IFN- produced in response toin vitro OK-432 stimulation.In vitro OK-432-stimulated IFN- production and the increase of CD8+DR+T cells in number in peripheral blood could be proposed as predictive indicators for the disappearance of HBe Ag. |
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Keywords: | activated T cells clearance of hepatitis B envelope antigen(HBe Ag) hepatitis B surface antigen(HBe Ag) carriers OK-432 |
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