| Abstract: | Distribution of chlorlincomycin in intact rats and animals with an impaired hormonal balance was studied. Estradiol or hydrocortizon acetate were administered repeatedly to the animals in large doses with a purpose of inducing pathological conditions. Chlorlincomycin was administered intravenously for 11 days in a dose of 15 mg/kg. The antibiotic levels in the blood serum and organs of the rats were determined at various intervals after the drug administration. The hormones induced changes in the sexual cycle. Hydrocortizon acetate markedly changed the animal weight and the weight coefficient of the internal organs. The kinetics of chlorlincomycin in the animals with hormonal impairments induced by estradiol or hydrocortizon acetate changed insufficiently as compared to that in the intact rats. Individual fluctuations in the antibiotic distribution was observed in the animals treated with hydrocortizon acetate. The levels of chlorlincomycin in the blood of the weakest animals were higher. No cumulation of the drug was noted. |
