Changes in the hormonal function of the hypophysis-adrenal system by administration of cortisol in 'fixed' phases of the postnatal ontogenesis in rats |
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Authors: | Ordian N E Pivina S G Rakitskaia V V Shaliapina V G |
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Institution: | I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia. |
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Abstract: | Administration of cortisol on the 13th, 15th, and 17th days of postnatal ontogenesis was shown to exert a long-lasting modifying effect upon the hypophysis-adrenal system's (HAS) stress reactivity in the rat litter. The effect involved a longer duration of hormonal response to immobilisation stress: a longer-lasting elevation of the corticosterone level in the blood plasma suggesting a diminished sensitivity of the HAS to feed-back signal. In hippocampus, frontal cortex and hypothalamus of the experimental rats, a decrease in receptor binding of labeled corticosterone was revealed. |
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