PTEN function in mammalian cell size regulation |
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| Authors: | Backman Stéphanie Stambolic Vuk Mak Tak |
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| Affiliation: | Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Canada. sbackman@uhnres.utoronto.edu |
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| Abstract: | The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation. |
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