Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives |
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| Authors: | Yao Nian-Huan Liu Gang He Wen-Yi Niu Changqun Carlson James R Lam Kit S |
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| Affiliation: | Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, PR China. |
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| Abstract: | Twenty-five N-demethylvancomycin derivatives were synthesized on solid-support and their structures were determined by LC-MS/MS. Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis. |
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