Activation of polymorphonuclear neutrophils by contact with collagen I and degradation of collagen |
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| Authors: | J C Monboisse R Garnotel G Bellon J P Borel |
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| Affiliation: | Laboratoire de Biochimie, CNRS URA 610, UFR Médecine, Université de Reims Champagne-Ardenne. |
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| Abstract: | The contact of polymorphonuclear neutrophils with type I collagen molecules triggers the production of oxygen free radicals by these cells. This activation requires two short collagenic sequences and seems to involve a beta 2 integrin on the neutrophil membrane. Oxygen free radicals are capable to degrade collagen molecules into small peptides. This interaction takes place in inflammatory phenomena. |
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