Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8 |
| |
Authors: | Kenji Hayashida Toshihiro Nanki Hermann Girschick Sule Yavuz Takahiro Ochi Peter E Lipsky |
| |
Institution: | (1) Southwestern Medical Center, University of Texas, Dallas, Texas, USA;(2) Osaka University Medical School, Suita, Osaka, Japan; |
| |
Abstract: | Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|