Modification of tissue distribution of trace elements by cyclosporin in rats

Cyclosporin-induced hypomagnesaemia, as observed in patients, could also be induced in rats by intramuscular administration of the drug (20 mg/kg/d) for 12 d. moreover, cyclosporin administration induced modifications in the concentrations of other elements in tissues, particularly an increase in Mg, Cu, and Zn in the thymus and an increase in Mo in the spleen and Sr in the liver.