Interaction of perfluorooctanoic acid with human serum albumin |
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| Authors: | Ling-Ling Wu Hong-Wen Gao Nai-Yun Gao Fang-Fang Chen Ling Chen |
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| Affiliation: | (1) State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China;(2) Key Laboratory of Yangtze River Water Environment of Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China |
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| Abstract: | Background Recently, perfluorooctanoic acid (PFOA) has become a significant issue in many aspects of environmental ecology, toxicology, pathology and life sciences because it may have serious effects on the endocrine, immune and nervous systems and can lead to embryonic deformities and other diseases. Human serum albumin (HSA) is the major protein component of blood plasma and is called a multifunctional plasma carrier protein because of its ability to bind an unusually broad spectrum of ligands. |
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