Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species
(1) Department of Molecular Biosciences, University of Oslo, Blindernveien 31, Blindern, N-0316, Oslo, Norway;(2) Medical Genetics Laboratory, Department of Medical Genetics, Rikshospitalet University Hospital, N-0027, Oslo, Norway
Abstract:
Background
The urokinase plasminogen activator receptor associated protein (uPARAP)/Endo180 is a novel endocytic receptor that mediates collagen uptake and is implicated to play a role in physiological and pathological tissue-remodelling processes by mediating intracellular collagen degradation.