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Effect of polynucleotides and a basic protein on the condensation of phenylalanyl adenylate
Authors:Masahiro Ishigami  Nobuko Tonotsuka-Ohta  Kei Nagano  Masataka Kinjo
Institution:(1) Laboratory of Biology, Jichi Medical School, Minamikawachi-machi, 329-04 Tochigi-Ken, Japan;(2) Laboratory of Agricultural Chemistry, Faculty of Agriculture, Utsunomiya University, 320 Utsunomiya, Japan
Abstract:The effect of polyuridylate and of histone on the oligomerization of phenylalanyl adenylate was tested. Polyuridylate which pairs with adenine under suitable conditions showed no effect. Histone increased the rate of the polymerization whereas a neutral protein, albumin, had no effect. Simultaneous presence of nucleotides diminished the effect of histone. The implication of these results on the prebiotic polypeptide formation is discussed.
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