Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents |
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| Authors: | Sunduru Naresh Agarwal Anu Katiyar Sanjay Babu Nishi Goyal Neena Gupta Suman Chauhan Prem M S |
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| Institution: | Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 microg/mL. |
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