Effect of bile acids on the uptake of irinotecan and its active metabolite, SN-38, by intestinal cells |
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Authors: | Kobayashi K Ceryak S Matsuzaki Y Kudoh S Bouscarel B |
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Affiliation: | Department of Medicine, George Washington University Medical Center, Wahington, DC 20037, USA. |
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Abstract: | The intestinal transport of irinotecan (CPT-11) and its active metabolite, SN-38, has been previously reported (K. Kobayashi et al., Int. J. Cancer, 83 (1999) 491-496). In the present study, the effect of the two major primary bile acids, cholic acid (CA) and taurocholic acid (TCA), on the uptake of CPT-11 and SN-38 by hamster intestinal epithelial cells was investigated. These two bile acids at concentrations up to 200 microM did not directly alter the cellular uptake of CPT-11 and SN-38. However, under physiologically acidic intestinal pH conditions, micelle formation induced by 20 mM TCA significantly reduced the cellular uptake of CPT-11 and SN-38 by 60% and 80%, respectively. |
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