Control of protein synthesis in reticulocyte lysates: the effect of nucleotide triphosphates on formation of the translational repressor. |
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Authors: | K Balkow T Hunt R J Jackson |
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Institution: | Department of Biochemistry, Tennis Court Road, Cambridge, England |
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Abstract: | High concentrations (1–2mM) of GTP completely prevented the decline in protein synthesis which occurs in a reticulocyte lysate incubated in the absence of haemin. The effect of GTP was diminished by raising the concentration of ATP. When formation of the haemin-controlled translational repressor was studied as a partial reaction using post-ribosomal supernatant, it was found that GTP acted by blocking repressor formation, whilst ATP was found to stimulate this process. |
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