Heavy metal mutagenicity: insights from bioinorganic model chemistry |
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Authors: | Müller J Sigel R K Lippert B |
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Affiliation: | Fachbereich Chemie, Universit?t Dortmund, Germany. |
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Abstract: | The mutagenicity of metal species may be the result of a direct interaction with the target molecule DNA. Possible scenarios leading to nucleobase mispairing are discussed, and selected examples are presented. They include changes in nucleobase selectivity as a consequence of alterations in acid-base properties of nucleobase atoms and groups involved in complementary H bond formation, guanine deprotonation, and stabilization of rare nucleobase tautomers by metal ions. Oxidative nucleobase damage brought about by metal species will not be considered. |
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