A progestin effect on lactate dehydrogenase in the human breast cancer cell line T-47D |
| |
| Authors: | R D Hagley M R Moore |
| |
| Institution: | 1. Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier Universitaire de Québec Research Centre (CHUQ, CHUL), and Faculty of Medicine, Laval University, Quebec City, Quebec, G1 V 4G2, Canada;2. Center of Excellent for Molecular Diagnostics, Department of Pathology, Peking University Third Hospital, Beijing, 100091, China;1. Endocrinology and Nephrology, CHU de Quebec-Research Center (CHUL), 2705 Boulevard Laurier, Québec City, Québec, G1V 4G2, Canada;2. Department of Molecular Medicine, Faculty of Medicine, Université Laval, 1050 avenue de la Médecine, Québec City, Québec, G1V 0A6, Canada;3. Centre de recherche sur le cancer de l''Université Laval, 9, rue McMahon, Québec City, Québec, G1R 3S3, Canada |
| |
| Abstract: | The human breast cancer cell line T-47D has high levels of progesterone receptor even in the absence of exogenously added estrogen. Because of this it is a good line in which to study aspects of progestin action. It has been shown by others that lactate dehydrogenase in MCF-7 cells is responsive to estrogen but not to progesterone. Other proteins in other systems have been found to be responsive to both estrogen and progesterone, often requiring priming by estrogen, presumably to produce sufficiently high quantities of progesterone receptor. Reasoning that lactate dehydrogenase in T-47D cells might be stimulated by progestins alone at physiological levels since these cells already have high levels of progesterone receptor, we now report that this is indeed the case. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
