Co-expression of vimentin and cytokeratins in M cells of rabbit intestinal lymphoid follicle-associated epithelium |
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| Authors: | Mark A Jepson Caroline M Mason Mark K Bennett Nicholas L Simmons and Barry H Hirst |
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| Institution: | (1) Gastrointestinal Drug Delivery Research Centre, University of Newcastle-upon-Tyne, Medical School, NE2 4HH Newcastle-upon-Tyne, UK;(2) Department of Physiological Sciences, University of Newcastle-upon-Tyne, Medical School, NE2 4HH Newcastle-upon-Tyne, UK;(3) Division of Pathology, University of Newcastle-upon-Tyne, Medical School, NE2 4HH Newcastle-upon-Tyne, UK |
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| Abstract: | Summary Membranous epithelial (M) cells within the follicle-associated epithelium which overlies gut-associated lymphoid tissue in Peyer's patches and of appendix have been shown by immunocytochemical staining, in rabbit, to contain both vimentin- and cytokeratin-type intermediate filaments. The specificity of vimentin immunostaining has been confirmed by blocking with purified vimentin and by immunoblotting. No evidence was obtained for the expression of vimentin in rat, mouse or human M cells. The possible significance of vimentin-expression in these specialized epithelial cells and the potential use of vimentin as a positive marker for M cells are discussed. |
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