| 血小板生成刺激因子对巨核血小板系统体外生成的影响 |
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| 引用本文： | 涂强,张卿西.血小板生成刺激因子对巨核血小板系统体外生成的影响[J].生理学报,1990,42(4):368-373. |
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| 作者姓名： | 涂强 张卿西 |
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| 作者单位： | 北京放射医学研究所 北京
(涂强)，北京放射医学研究所 北京(张卿西) |
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| 摘 要： | 本 文应用血小板生成液体培养体系及纯化的血小板生成刺激因子(TSF)研究了 TSF对巨核细胞成熟及血小板生成的作用。TSF 在0.5—2U/ml 浓度范围内能够刺激巨核细胞DNA 合成,胞浆成熟,胞体直径增加以及血小板直径增加,但对巨核细胞与血小板计数没有影响。实验表明 TSF 作为一种血小板生成素,通过促进巨核细胞分化成熟,以增加血小板体积的方式,促进血板小生成。
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| 关 键 词： | 血小板生成 巨核细胞 TSF |
STIMULATION OF MEGAKARYOCYTE MATURATION AND THROMBOPOIESIS IN VITRO BY THROMBOCYTOPOIESIS-STIMULATING FACTOR |
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| TU QIANG,ZHANG QING-XI.STIMULATION OF MEGAKARYOCYTE MATURATION AND THROMBOPOIESIS IN VITRO BY THROMBOCYTOPOIESIS-STIMULATING FACTOR[J].Acta Physiologica Sinica,1990,42(4):368-373. |
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| Authors: | TU QIANG ZHANG QING-XI |
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| Institution: | Institute of Radiation Medicine, Beijing. |
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| Abstract: | The liquid culture system with platelet production was used to investigate the effects of thrombocytopoiesis-stimulating factor (TSF) on terminal cytoplasmic maturation of megakaryocyte and thrombopoiesis. TSF, at concentrations from 0.5-2.0 U/ml, stimulated megakaryocyte DNA synthesis, cytoplasmic maturation and isotopic incorporation into platelets, whereas megakaryocyte and platelet count remained unchanged. Our data indicate that TSF, stimulates platelet production by increasing the size of platelet. |
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| Keywords: | thrombocytopoiesis-stimulating factor megakaryocyte thrombopoiesis liquid culture |
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