Robust operation of fed batch fermenters

Optimisation of fed batch fermenters can substantially increase the profitability of these processes. Optimal control of a fed batch fermenter is usually based on a nominal process model. Parameter uncertainties are not taken into account. Simulation studies show that results obtained with fixed nominal model parameters can be quite sensitive to the uncertainty in parameter values. This paper presents a method for obtaining robust optimal control profiles in the presence of uncertainty in the model parameters. The proposed approach is illustrated with a case study. It is also shown that feedback controllers can reduce the effect of the uncertainties.