Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity |
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| Authors: | Isaac M Slassi A O'Brien A Edwards L MacLean N Bueschkens D Lee D K McCallum K De Lannoy I Demchyshyn L Kamboj R |
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| Institution: | NPS Allelix Corp., Mississauga, ON, Canada. misaac@allelix.com |
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| Abstract: | A series of pyrrolo3,2,1-ij]quinoline derivatives was synthesized, evaluated for their activity against the 5-HT2c and 5-HT2a, receptors and found to be agonists at 5-HT2c with selectivity over 5-HT2a. |
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