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Hydrogels Composed of Cyclodextrin Inclusion Complexes with PLGA-PEG-PLGA Triblock Copolymers as Drug Delivery Systems |
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| Authors: | Elham Khodaverdi Farnaz Sadat Mirzazadeh Tekie Farzin Hadizadeh Haydar Esmaeel Seyed Ahmad Mohajeri Sayyed A Sajadi Tabassi Gholamhossein Zohuri |
| Institution: | 1. Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 2. Nanotechnology Research Centre, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 3. Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 4. Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 5. Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 6. Department of Chemistry, Faculty of Science, Ferdowsi University, Mashhad, Iran |
| Abstract: | Although conventional pharmaceuticals have many drug dosage forms on the market, the development of new therapeutic molecules and the low efficacy of instant release formulations for the treatment of some chronic diseases and specific conditions encourage scientists to invent different delivery systems. To this purpose, a supramolecular hydrogel consisting of the tri-block copolymer PLGA-PEG-PLGA and α-cyclodextrin was fabricated for the first time and characterised in terms of rheological, morphological, and structural properties. Naltrexone hydrochloride and vitamin B12 were loaded, and their release profiles were determined. |
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