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Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress
Institution:1. Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA;2. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA;3. The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA;4. Institute for Antiviral Research, Utah State University, Logan, UT 84335, USA;5. Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA;6. Integral Molecular, Philadelphia, PA 19104, USA;7. The Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 165261, USA;8. Department of Immunology, University of Pittsburgh, Pittsburgh, PA 165261, USA;9. Department of Medicine, Washington University, St. Louis, MO 63110, USA;10. Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA;11. Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA;12. Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA;13. Center of Structural Biology, Vanderbilt University, Nashville, TN, USA;14. Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA;15. Department of Chemistry, Vanderbilt University, Nashville, TN, USA;16. Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Germany
Abstract:
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  • Keywords:alphavirus  human monoclonal antibodies  non-neutralizing antibodies  cross-reactive antibodies  post-exposure prophylaxis
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