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Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
Affiliation:1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;2. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA;3. Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China;4. Institute of Immunology, University of Science and Technology of China, Hefei, China;5. National Institute of Gastroenterology, “S. de Bellis” Research Hospital, Castellana Grotte, Bari 70013, Italy;6. Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA;7. The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA;8. CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;9. Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA;10. Howard Hughes Medical Institute, New Haven, CT, USA
Abstract:
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  • Keywords:NLRP6  dsRNA  liquid-liquid phase separation  LLPS  inflammasome  MHV  RV  IDRs
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