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Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb
Affiliation:1. Max Planck Research Unit for Neurogenetics, Frankfurt, Germany;2. Department of Neurosciences, Experimental Otorhinolaryngology, Rhinology Research, KU Leuven, Leuven, Belgium;3. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium;4. Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Unit, KU Leuven, Leuven, Belgium;5. Department of Pathology, University Hospitals Leuven, Leuven, Belgium;6. Department of Otorhinolaryngology, Head and Neck Surgery, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium;7. NanoString Technologies Inc., Seattle, WA, USA;8. Department of Anesthesiology and Intensive Care Medicine, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium;9. Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium;10. Department of Cellular and Molecular Medicine, Laboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium;11. Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium;12. Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium;13. Department of Laboratory Medicine and National Reference Centre for Respiratory Pathogens, University Hospitals Leuven, Leuven, Belgium;14. Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Bacteriology and Mycology, KU Leuven, Leuven, Belgium;15. Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium;16. Department of Anesthesia, University Hospitals Leuven, Leuven, Belgium;17. Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium;18. Department of Imaging and Pathology, Laboratory of Neuropathology and Leuven Brain Institute, KU Leuven, Leuven, Belgium;19. Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium
Abstract:
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  • Keywords:COVID-19  SARS-CoV-2  coronavirus  B.1.1.7  olfactory sensory neuron  olfactory receptor  sustentacular cell  olfactory bulb  leptomeninges  UGT2A1
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